Glutamate receptor subtypes and conformation of glutamate agonists: Discovery of new potent agonists
نویسندگان
چکیده
منابع مشابه
Oxidative stress induced by glutamate receptor agonists.
The effect of various selective glutamate agonists upon the rate of generation of reactive oxygen species (ROS), was examined in an isolated synaptoneurosomal (microsac) fraction derived from rat cerebral cortex. The rates of ROS generation were determined by a fluorescent probe. Agonists specific for each of the three major glutamate inotropic receptor sites (NMDA, kainic acid, alpha-amino-3-h...
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The pedunculopontine nucleus (PPN) is involved in the generation and maintenance of waking and rapid eye movement (REM) sleep, forming part of the reticular activating system. The PPN receives glutamatergic afferents from other mesopontine nuclei, and glutamatergic input is believed to be involved in the generation of arousal states. We tested the hypothesis that, from postnatal days 9 to 17 in...
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27 The pedunculopontine nucleus (PPN) is involved in the generation and maintenance of 28 waking and rapid eye movement (REM) sleep, forming part of the reticular activating system. 29 The PPN receives glutamatergic afferents from other mesopontine nuclei and glutamatergic 30 input is believed to be involved in the generation of arousal states. We tested the hypothesis 31 that, from postnatal d...
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Restoring the balance between excitatory and inhibitory circuits in the basal ganglia, following the loss of dopaminergic (DA) neurons of the substantia nigra pars compacta, represents a major challenge to treat patients affected by Parkinson's disease (PD). The imbalanced situation in favor of excitation in the disease state may also accelerate excitotoxic processes, thereby representing a pot...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1989
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)56761-0